Prof. Kenneth To investigates the regulation of multidrug resistance (MDR) transporters in cancer tissues. Aberrant expression of MDR transporters in cancer cells is known to adversely affect patients’ response to cancer chemotherapy. Advanced understanding of the regulation of MDR transporters could allow therapeutic interventions to potentiate anticancer drug efficacy.
Prof. Xiaoyu Yan developed new modeling approach to characterize the pharmacokinetics and pharmacodynamics (PK/PD) of drugs. This work will help to make better prediction for drug response at various dosing regimens in clinical trials.
Prof. Joyce You identifies predictors, including adherence level, genotypes, clinical factors and demographic factors, on drug responses of statin, oral antiplatelets, oral anticoagulants and antimicrobial agents. Her work provides information to assist clinicians in optimizing medication therapy.
Prof. Joan Zuo tests drugs to see which may be pumped out of the brain by transporters. Drugs that are not exported might be more effective in patients who have high amounts of transporters and who continue to suffer despite drug treatment. Finding on thesemay identify pathways of resistance and allow design of drugs to overcome resistance and thus treat patients more effectively.