Research Highlights

Prof. Yan Xiaoyu

【Population-based meta-analysis of chloroquine: informing chloroquine pharmacokinetics in COVID-19 patients】

The outbreak of coronavirus disease 2019 (COVID-19) has quickly become a global pandemic since December 2019. Chloroquine is recommended to treat COVID-19 by the National Health Commission of the People’s Republic of China and issued as emergency use authorization (EUA) by The US Food and Drug Administration. Prof. Yan Xiaoyu from CUHK Pharmacy, cooperating with researchers from Drug Clinical Trial Center of Beijing Peking University Third Hospital and China Pharmaceutical University, developed a population pharmacokinetics (PK) model to characterize the Chloroquine pharmacokinetics (PK) in COVID-19 patients using a population-based meta-analysis approach.

Understanding the Chloroquine PK in COVID-19 patients is essential to study its exposure–efficacy/safety relationship and provide a basis for a possible dosing regimen optimization. With sparse PK samples available, a population PK model allows addressing critical gaps in experimental PK data, which was pulled from literature and a first clinical trial conducted in COVID-19 patients.

Model-based simulation shows that the concentrations under the currently recommended dosing regimen are below the safety margin for side effects, which suggests that these dosing regimens are generally safe. The derived population PK model should allow for the assessment of pharmacokinetics–pharmacodynamics (PK-PD) relationships for Chloroquine when given alone or in combination with other agents to treat COVID-19.

Full research paper published in the European Journal of Clinical Pharmacology:





相關論文已於國際學術期刊European Journal of Clinical Pharmacology發表:

Simulations of chloroquine PK under various dosing regimens. The black dashed line represents the 50th percentile and the shaded area represents the range between 5th and 95th percentile. The solid line represents the safety concentration threshold of 400 mg/ml and 800 mg/ml

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