Prof. LEUNG Shui Yee, Sharon

About me

Prof. Sharon Leung

LEUNG Shui Yee, Sharon 梁水意

B.Eng. (Chemical Eng.) (Hons.), Ph.D.
Assistant Professor
School of Pharmacy
Faculty of Medicine
The Chinese University of Hong Kong

Tel: (852) 3943 9795
Fax:(852) 2603 5295
Email: sharon.leung@cuhk.edu.hk

Personal Details

Dr. Sharon Shui Yee Leung received her B. Eng. (Chemical Engineering) in 2007 from the Hong Kong University of Science and Technology and completed her PhD (Chemical Engineering) in the University of Sydney in 2012. After her PhD, she joined the Faculty of Pharmacy in the University of Sydney with interest in developing technology platforms to produce engineering particles for respiratory delivery. In 2014, she was awarded a Postdoctoral Fellowship from the Faculty of Pharmacy to develop technologies for aerosol delivery of bacteriophages to combat multidrug-resistant (MDR) bacteria. Sharon joined the School of Pharmacy at the Chinese University of Hong Kong in April 2018. She hopes to incorporate her microfluidic and formulation design research to advance the science and potential application of phage therapy to address the MDR threats.

Research

Research Interests

Sharon is keen to incorporate her engineering and microfluidics background for the production of inhalable drug powders with engineered features, such as using of particles with controlled porosity as therapeutic carriers and polymer encapsulation for control release of active ingredients.

She is interested in examining the mechanisms responsible for stabilisation of bacteriophages in powder formulations to enable optimization of process parameters for production of inhalable phage powders. Recently, she is investigating to encapsulation of bacteriophages into liposomes using a microfluidic approach to target intracellular pathogens, such as mycobacterium tuberculosis.

 

Teaching

Teaching

Bachelor of Pharmacy Programme

  • PHAR2213 Pharmaceutical Product Development & Manufacturing
  • PHAR4911 (Research Project I) and PHAR4912 (Research Project II)

Master of Science in Pharmaceutical Manufacturing and Quality

  • PHAR5130 Overview of Drug Development

Publications

Representative Publications

  1. Leung SSY, Parumasivam T, Nguyen A, Gengenbach T, Carter EA, Carrigy NB, Wang H, Vehring R, Finlay WH, Morales S, Britton WJ, Kutter E, Chan H-K. Effect of Storage Temperature on the Stability of Spray Dried Bacteriophage Powders. Euro J Pharms Biopharm. 127: 213-222.
  2. Astudillo A*, Leung SSY*, Kutter E, Morales S and Chan HK. ­Nebulization effects on structural stability of bacteriophage PEV44. Euro J Pharms Biopharm. 125: 124-130. * equal contribution.
  3. Leung SSY, Parumasivam T, Gao FG, Carter EA, Carrigy NB, Vehring R, Finlay WH, Morales S, Britton WJ, Kutter E, Chan HK. 2017. Effects of storage conditions on the stability of spray dried, inhalable bacteriophage powders. International Journal of Pharmaceutics. 521: 141-149.
  4. Leung SSY, Wong J, Guerra HV, Samnick K, Prud’homme RK, Chan HK. 2017. Porous mannitol carrier for pulmonary delivery of cyclosporine A nanoparticles. AAPS Journal. 19: 578-586.
  5. Parumasivam T, Leung SSY, Tang P, Mauro C, Britton W, Chan HK. 2017. The delivery of high-dose dry powder antibiotics by a low-cost generic inhaler. AAPS Journal. 19: 191-202.
  6. Parumasivam T, Leung SSY, Quan DH, Triccas JA, Britton WJ, Chan HK. 2016. Rifapentine-loaded PLGA microparticles for tuberculosis inhaled therapy: Preparation and in vitro aerosol characterization. European Journal of Pharmaceutical Sciences. 88: 1-11.
  7. Leung SSY, Parumasivam T, Gao FG, Carrigy NB, Vehring R, Finlay WH, Morales S, Britton WJ, Kutter E, Chan HK. 2016. Production of inhalation phage powders using spray freeze drying and spray drying techniques for treatment of respiratory infections. Pharmaceutical Research. 33: 1486-1496.

More Publications

Supplementary Information

Award

2018 USyd-CUHK Partnership Collaboration Awards
2014 Postdoctoral Fellowship, Faculty of Pharmacy University of Sydney
2008-2011 Endeavour International Postgraduate Research Scholarship, The Australian Department of Education, Science and Training (2008-2011)
2008-2011 International Postgraduate Award, The University of Sydney (2008-2011).

 

 

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